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[연구부세미나]16.10.6._이은이 박사
제목 [연구부세미나]16.10.6._이은이 박사
부서 대외협력팀 등록일자 2016-10-06
첨부파일 jpg 58222_연자 소개.JPG jpg IBS 이은이 박사 강연.JPG jpg 이은이, 구자욱, 이석원, 윤종혁 박사.JPG
[연구부세미나]16.10.6._이은이 박사 이미지 1

[연구부세미나]16.10.6._이은이 박사 이미지 2

[연구부세미나]16.10.6._이은이 박사 이미지 3

[뇌질환연구부 제3차 세미나]
- 일시 : 2016. 10. 6. (목) 11:00~12:00
- 연자 : 이은이 박사 (IBS)
- 주제 : The speculation of social neural correlates in the mPFC of autistic mouse

- 요약 : Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known on mPFC neural correlates of social behavior. In the present study, we examined single neuron activity in the mPFC of mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate their discharge rates when approaching a stranger mouse, but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely-used social interaction paradigm. This finding might be useful for future investigations of mPFC neural processes underlying social interaction in health and disease.
An increase in the ratio of synaptic excitation and inhibition (E/I ratio) in pyramidal neurons in the medial prefrontal cortex (mPFC) induced by optogenetic stimulation has been associated with enhanced baseline gamma rhythms in the brain and impaired social interaction in mice. However, whether these principles hold true ?for animal models of autism spectrum disorders (ASDs) is unclear. Here we report that Shank2-mutant (Shank2–/–) mice, a mouse model of ASDs, show increased synaptic E/I ratio in mPFC pyramidal neurons and decreased inhibitory neuronal firing. The social deficits in Shank2–/– mice are rescued by increasing GABAergic output of parvalbumin (PV)-positive interneurons in the mPFC by optogenetic stimulation. These results suggest that Shank2–/– mice show increased synaptic E/I ratio in the mPFC associated with reduced sensory target-induced local oscillations, and that increased inhibitory input from PV-positive interneurons onto mPFC pyramidal neurons can correct social deficits in these mice, a mouse model of ASDs.
 
 
[연구부세미나]16.10.6._이은이 박사
윗글 2016년 한국뇌연구원 시무식
아랫글 [연구부세미나] 16.9.22._ 김지은 박사
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