Neurobiology of Alzheimer's disease Laboratory

PUBLICATIONS

papers list
27	Control of hippocampal pKr-2 expression reduces neurotoxic symptoms in 5XFAD mice Sehwan Kim#, Gyeong Joon Moon#, Hyung Jun Kim#, Do-Geun Kim#, Jaekwang Kim#, Youngpyo Nam#, Chanchal Sharma, Eunju Leem, Shinrye Lee, Kyu-Sung Kim, Chang Man Ha, Catriona McLean, Byung Kwan Jin, Won-Ho Shin, Dong Woon Kim, Yong-Seok Oh, Chang-Won Hong, Sang Ryong Kim (# co-first author) [British Journal of Pharmacology (2021) ] Abstract
26	Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction Sunil Bhurtel#, Eugene Bok#, Nikita Katila, Jaekwang Kim, Dong-Young Choi (# co-first author; *co-corresponding author) [Biochemical Pharmacology (2021) ] Abstract
25	C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons Eun Seon Kim, Chang Geon Chung, Jeong Hyang Park, Byung Su Ko, Sung Soon Park, Yoon Ha Kim, In Jun Cha, Jaekwang Kim, Chang Man Ha, Hyung-Jun Kim, Sung Bae Lee [Human Molecular Genetics (2021) ] Abstract
24	Role of the Lipid Membrane and Membrane Proteins in Tau Pathology Eugene Bok, Eunju Leem, Bo-Ram Lee, Ji Min Lee, Chang Jae Yoo, Eun Mi Lee, Jaekwang Kim [Frontiers in Cell and Developmental Biology (2021) ] Abstract
23	α-synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment Razaul Karim, Elly E Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C Troncoso, Michael K Lee [Molecular Neurodegeneration (In press) (2020) ] Abstract
22	Actin-Microtubule Crosslinker Pod-1 Tunes PAR-1 Signaling to Control Synaptic Development and tau-Mediated Synaptic Toxicity Ha-Young Kang, Hyung-Jun Kim, Kiyoung Kim, Seung-Il Oh, Sunggyu Yoon, Jaekwang Kim, Sangwoo Park, Yeongmi Cheon, Song Her, Mihye Lee, Bingwei Lu, Seongsoo Lee [Neurobiology of Aging (In press) (2020) ] Abstract
21	PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies Shinrye Lee, Yu-Mi Jeon, Sun Joo Cha, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim & Hyung-Jun Kim [Autophagy (2019) ] Abstract
20	Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link Eugene Bok+, Myungjin Jo+, Shinrye Lee, Bo-Ram Lee, Jaekwang Kim, Hyung-Jun Kim (+equally contributed, *co-corresponding authors) [Int J Mol Sci (2019) ] Abstract
19	miR-186 is decreased in aged brain and suppresses BACE1 expression Jaekwang Kim, Hyejin Yoon, Dah-eun Chung, Jennifer L. Brown, Krystal C Belmonte, Jungsu Kim (“Editorial highlight”) [J Neurochem, 137 (3): 436-45 (2016) ] Abstract
18	miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) Jaekwang Kim, Fabienne C. Fiesel, Krystal C Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer, Jungsu Kim (*co-corresponding authors) [Mol Neurodegener. 11(1):55 (2016) ] Abstract
17	Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-beta Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease Gongbo Li, Chaeyoung Kim, Jaekwang Kim, Hyejin Yoon, Huadong Zhou, Jungsu Kim [J Alzheimers Dis 46:109-122 (2015) ] Abstract
16	microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain Jaekwang Kim, Hyejin Yoon, Takahiro Horie, Jack M. Burchett, Jessica L. Restivo, Noemi Rotllan, Cristina M. Ramirez, Philip B. Verghese, Masafumi Ihara, Hyang-Sook Hoe, Christine Esau, Carlos Fernandez-Hernando, David M. Holtzman, John R. Cirrito, Koh Ono, Jungsu Kim (“Featured Article”) [J Neurosci. 35(44): 14717-26 (2015) ] Abstract
15	The E3 ubiquitin ligase Idol controls brain LDL receptor levels, ApoE clearance and Aβ amyloidosis Jinkuk Choi, Jie Gao, Jaekwang Kim, Cynthia Hong, Jungsu Kim, Peter Tontonoz (contributed equally to this work) [Sci Transl Med. 7(314): 314ra184 (2015) ] Abstract
14	Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms Jaekwang Kim, Hyejin Yoon, Jacob Basak, Jungsu Kim [. Mol. Cells. 37: 767-776 (2014) ] Abstract
13	Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity Anuj K. Sharma, Jaekwang Kim, John T. Prior, Nicholas J. Hawco, Nigam P. Rath, Jungsu Kim, and Liviu M. Mirica [Inorg Chem. 53(21): 11367-76 (2014) ] Abstract
12	Anuj K. Sharma, Stephanie T. Pavlova, Jaekwang Kim, Jungsu Kim, and Liviu M. Mirica The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity [Metallomics 5: 1529-1536 (2013) ] Abstract
11	Role of Autophagy in Alzheimer’s Disease Jaekwang Kim, Hyejin Yoon, Jungsu Kim [Curr. Enz. Inhib. 9: 55-66 (2013) ] Abstract
10	Mutagenesis by imprecise excision of the piggyBac transposon in Drosophila melanogaster Heuijong Kim, Kiyoung Kim, Jaekwang Kim, Song-Hee Kim, Jeongbin Yim [Biochem. Biophys. Res. Commun. 417: 335-339 (2012) ] Abstract
9	Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease Kiyoung Kim, Song-Hee Kim, Jaekwang Kim, Heuijong Kim, Jeongbin Yim [J. Biol. Chem. 287: 6628-6641 (2012) ] Abstract
8	Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide Anuj K. Sharma, Stephanie T. Pavlova, Jaekwang Kim, Darren Finkelstein, Nicholas J. Hawco, Nigam P. Rath, Jungsu Kim, and Liviu M. Mirica [J. Am. Chem. Soc. 134: 6625-6636 (2012) ] Abstract
7	miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression Jaekwang Kim, Hyejin Yoon, Cristina M. Ramirez, Sang-Mi Lee, Hyang-Sook Hoe, Carlos Fernandez-Hernando, Jungsu Kim [Exp. Neurol. 235, 476-483 (2012) ] Abstract
6	Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis Jungsu Kim, Adam E.M. Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, David M. Holtzman [J. Exp. Med. 209: 2149-2156 (2012) ] Abstract
5	Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2 . David Ramonet, Joao Paulo L. Daher, Brian M. Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletnikova, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A. Swing, M. Flint Beal, Juan C. Troncoso, J. Michael McCaffery, Nancy A. Jenkins, Neal G. Copeland, Dagmar Galter, Bobby Thomas, Michael K. Lee, Ted M. Dawson, Valina L. Dawson, Darren J. Moore [PLos One. 6: e18586 (2011) ] Abstract
4	Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila Jaekwang Kim* and Sang Ick Park, Chiyoung Ahn, Heuijong Kim, and Jeongbin Yim (contributed equally to this work) [J. Biol. Chem. 284: 23426-23435 (2009) ] Abstract
3	Molecular Analysis of mps Operon Involved in Monapterin Synthesis in Escherichia Coli . Chiyoung Ahn, Mikyoeng Kim, Soojin Lee, Jaekwang Kim, Deogsu Hwang, Kyungmoon Park, Jeongbin Yim [Pteridines. 17:16-19 (2006) ] Abstract
2	Identification and characteristics of the structural gene for the Drosophila eye color mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases Jaekwang Kim, Hyunsuk Suh, Songhee Kim, Kiyoung Kim, Chiyoung Ahn and Jeongbin Yim (*contributed equally to this work) [Biochemical J. 398: 451-460 (2006) ] Abstract
1	The nuclear RNase III Drosha initiates microRNA processing Yoontae Lee, Chiyoung Ahn, Jinju Han, Hyounjeong Choi, Jaekwang Kim, Jeongbin Yim, Junho Lee, Patrick Provost, Olof Radmark, Sunyoung Kim and V. Narry Kim [Nature. 425: 415-419 (2003) ] Abstract