Press Releases
하위 메뉴
Title | Identification of Autophagy Gene Regulation Mechanism Related to Dementia and Lou Gehrig‘s Disease | ||
---|---|---|---|
Department | Public Relations & Cooperation Team | Date | 2019-07-18 |
Attachments | [Press Release] Identification of Autophagy Gene Regulation Mechanism Related to Dementia and Lou Gehrig’s Disease.pdf | ||
Identification of Autophagy Gene Regulation Mechanism Related to Dementia and Lou Gehrig's Disease- An international Research Team led by Dr. Yun Ha Jeong at Korea Brain Research Institute has published the results of its research in 'Autophagy'
- Expected to develop the treatment for neurodegenerative disease utilizing TDP-43 protein □ Korea Brain Research Institute (KBRI, President Seo Pan-ghill) announced on July 10 that the international joint research team ‘where‘ Senior Researcher Yun Ha Jeong and John * Autophagy: It refers to the phenomenon ‘where‘ a cell discomposes and recycles unnecessary organelles or components. It can be regarded as the self-cleaning taking place within the cell. ○ The research outcome was published in the July issue of ‘Autophagy’, which is an international journal and the name of the paper and authors are as follows. * Paper: Upregulation of ATG7 Attenuates Motor Neuron Dysfunction Associated with Depletion of TARDBP/TDP-43 * Author: Aneesh Donde*, Mingkuan Sun*, Yun Ha Jeong* (co-first author), Xinrui Wen, Jonathan Ling, Sophie Lin, Kerstin Braunstein, Shuke Nie, Sheng Wang, Liam Chen and Philip C. Wong (corresponding author) □ The research team found that when the genes are manipulated to make sure that a certain protein called TDP-43* is not created in mice and fruit flies, then the activity of gene ATG7, which is essential for cell autophagy, was inhibited and neuronal degeneration occurred. * TDP-43 is a tran ional regulation protein and it is known as the major pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). * ATG7: Essential gene for autophagy ○ On the contrary, when the gene is manipulated to increase the ATG7 gene expression for activation of autophagy in fruit flies, for which the TBPH* gene expression is inhibited, it is found that neurodegenerative and ataxia symptoms were improved. * TBPH: Gene of fruit flies that is equivalent to TDP-43 present in humans. □ The result of this study is meaningful in that the study confirmed the fact that TDP-43 protein regulates the activation of ATG7, which is responsible for the autophagy of neurons as well as the specific process of neuronal degeneration at the gene level. ○ Cells improve □ Dr. Yun Ha Jeong of the KBRI expected that “this research would contribute towards the development of a new treatment for neuro-degenerative diseases, aiming to activate the autophagy function of cell”. |
Next | Mechanism of epilepsy causing membrane protein is discovered. |
---|---|
Previous | Discovery of a gene related to 'individual differences in depression' |
- contact person :
- 이승재 Tel. 053-980-8218